Reduction of alpha-synuclein oligomers in preclinical models of Parkinson’s disease by electrical stimulation in vitro and deep brain stimulation in vivo

Background: Deep brain stimulation (DBS) has been widely used to manage debilitating neurological symptoms in movement disorders such as Parkinson's disease (PD). Despite its well-established symptomatic benefits, our understanding of the mechanisms underlying DBS and its possible effect on the accu...

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Autores principales:	Eun Jung Lee, David Hernán Aguirre-Padilla, Anton Fomenko, Grishma Pawar, Minesh Kapadia, Jimmy George, Andres M. Lozano, Clement Hamani, Lorraine V. Kalia, Suneil K. Kalia
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2024-03-01
Colección:	Brain Stimulation
Materias:	Alpha-synuclein Oligomers High frequency stimulation Deep brain stimulation Substantia nigra Subthalamic nucleus
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S1935861X24000160
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