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Binding Orientations and Lipid Interactions of Human Amylin at Zwitterionic and Anionic Lipid Bilayers

Increasing evidence suggests that the interaction of human islet amyloid polypeptide (hIAPP) with lipids may facilitate hIAPP aggregation and cause the death of pancreatic islet β-cells. However, the detailed hIAPP-membrane interactions and the influences of lipid compositions are unclear. In this s...

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Autori principali: Zhenyu Qian, Yan Jia, Guanghong Wei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley 2016-01-01
Serie:Journal of Diabetes Research
Accesso online:http://dx.doi.org/10.1155/2016/1749196
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