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Higher levels of GluN1 splice cassettes, C2 and C2’, in hippocampus of aged mice were associated with poor spatial reference memory

Cognitive decline during aging has been linked to changes in the N-methyl-D-aspartate receptor (NMDAR). Age-related changes in the GluN1 splice cassette proteins have been described in crude synaptosomes, but synaptic and extrasynaptic NMDARs have different impacts on synaptic plasticity. The presen...

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Hlavní autoři: Kathy R. Magnusson, Daniel R. Zamzow
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2025-10-01
Edice:Brain Research Bulletin
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On-line přístup:http://www.sciencedirect.com/science/article/pii/S0361923025003144
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