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Combining TNF-α silencing with Wnt3a overexpression: a promising gene therapy for particle-induced periprosthetic osteolysis

Wear particle-induced periprosthetic osteolysis is a prevalent issue that frequently leads to the failure of joint replacements, necessitating the development of effective therapeutic strategies. In this study, we established a mouse model of prosthetic loosening and evaluated the therapeutic effect...

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Hlavní autoři: Ping Chen, Long Wu, Shuai Zhang, Qunhua Jin, Kening Sun
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2025-03-01
Edice:Frontiers in Cell and Developmental Biology
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On-line přístup:https://www.frontiersin.org/articles/10.3389/fcell.2025.1511577/full
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