Matching for HLA-DR excluding diabetogenic HLA-DR3 and HLA-DR4 predicts insulin independence after pancreatic islet transplantation

IntroductionIn pancreatic islet transplantation, the exact contribution of human leukocyte antigen (HLA) matching to graft survival remains unclear. Islets may be exposed to allogenic rejection but also the recurrence of type 1 diabetes (T1D). We evaluated the HLA-DR matching, including the impact o...

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Autors principals:	Cassandra Ballou, Franca Barton, Elizabeth H. Payne, Thierry Berney, Jean Villard, Raphael P. H. Meier, David Baidal, Rodolfo Alejandro, Mark Robien, Thomas L. Eggerman, Malek Kamoun, Yannick D. Muller
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2023-03-01
Col·lecció:	Frontiers in Immunology
Matèries:	islet transplantation HLA-DR4 HLA-DR3 insulin independence type 1 diabetes insulin
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1110544/full
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