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Lab-scale siRNA and mRNA LNP manufacturing by various microfluidic mixing techniques – an evaluation of particle properties and efficiency

Lipid Nanoparticles (LNPs) are promising drug delivery systems for various RNAs such as small interfering (siRNA) and messenger RNA (mRNA). Microfluidic mixing is a common technique to encapsulate RNA in LNPs. However, high flow rates and lipid concentrations are used for LNP formation to control LN...

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Principais autores: David C. Jürgens, Leonie Deßloch, Diana Porras-Gonzalez, Joshua Winkeljann, Sebastian Zielinski, Matthias Munschauer, Andreas L. Hörner, Gerald Burgstaller, Benjamin Winkeljann, Olivia M. Merkel
פורמט: Artigo
שפה:Inglês
יצא לאור: Elsevier 2023-07-01
סדרה:OpenNano
נושאים:
siRNA
mRNA
LNP
Microfluidics
Lab-scale
גישה מקוונת:http://www.sciencedirect.com/science/article/pii/S2352952023000403
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