Lab-scale siRNA and mRNA LNP manufacturing by various microfluidic mixing techniques – an evaluation of particle properties and efficiency

Lipid Nanoparticles (LNPs) are promising drug delivery systems for various RNAs such as small interfering (siRNA) and messenger RNA (mRNA). Microfluidic mixing is a common technique to encapsulate RNA in LNPs. However, high flow rates and lipid concentrations are used for LNP formation to control LN...

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Egile Nagusiak:	David C. Jürgens, Leonie Deßloch, Diana Porras-Gonzalez, Joshua Winkeljann, Sebastian Zielinski, Matthias Munschauer, Andreas L. Hörner, Gerald Burgstaller, Benjamin Winkeljann, Olivia M. Merkel
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Elsevier 2023-07-01
Saila:	OpenNano
Gaiak:	siRNA mRNA LNP Microfluidics Lab-scale
Sarrera elektronikoa:	http://www.sciencedirect.com/science/article/pii/S2352952023000403
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