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Isoalantolactone induces apoptosis of non-small cell lung cancer cells by targeting EGFR and MET kinases and ROS generation

Extensive research efforts are necessary to develop effective treatments for non-small cell lung cancer (NSCLC), one of the most lethal malignancies. To address limitations of gefitinib (GEF) in NSCLC treatment, we investigated the anticancer activity of isoalantolactone (IAL) in HCC827 cells with o...

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Hlavní autoři: Na Yeong Lee, A-Young Nam, Goo Yoon, Jin Woo Park, Yung Hyun Choi, Joon-Seok Choi, Sang Hoon Joo, Jung-Hyun Shim
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2026-03-01
Edice:Heliyon
Témata:
Isoalantolactone
Non-small cell lung cancer
EGFR
MET
Cell cycle
Reactive oxygen species
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2405844026000538
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