Superiority of focused ion beam‐scanning electron microscope tomography of cardiomyocytes over standard 2D analyses highlighted by unmasking mitochondrial heterogeneity

Abstract Background Cardioprotection by preventing or repairing mitochondrial damage is an unmet therapeutic need. To understand the role of cardiomyocyte mitochondria in physiopathology, the reliable characterization of the mitochondrial morphology and compartment is pivotal. Previous studies mostl...

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Detalhes bibliográficos

Principais autores:	Jacqueline Heinen‐Weiler, Mike Hasenberg, Martin Heisler, Stephan Settelmeier, Anna‐Lena Beerlage, Hannah Doepper, Bernd Walkenfort, Andrea Odersky, Peter Luedike, Elke Winterhager, Tienush Rassaf, Ulrike B. Hendgen‐Cotta
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2021-08-01
coleção:	Journal of Cachexia, Sarcopenia and Muscle
Assuntos:	Cardiac mitochondria Focused ion beam‐scanning electron microscopy BNIP3 3D morphometry Mitochondrial energetics Mitochondrial dynamics
Acesso em linha:	https://doi.org/10.1002/jcsm.12742
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