Superiority of focused ion beam‐scanning electron microscope tomography of cardiomyocytes over standard 2D analyses highlighted by unmasking mitochondrial heterogeneity

Abstract Background Cardioprotection by preventing or repairing mitochondrial damage is an unmet therapeutic need. To understand the role of cardiomyocyte mitochondria in physiopathology, the reliable characterization of the mitochondrial morphology and compartment is pivotal. Previous studies mostl...

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主要な著者:	Jacqueline Heinen‐Weiler, Mike Hasenberg, Martin Heisler, Stephan Settelmeier, Anna‐Lena Beerlage, Hannah Doepper, Bernd Walkenfort, Andrea Odersky, Peter Luedike, Elke Winterhager, Tienush Rassaf, Ulrike B. Hendgen‐Cotta
フォーマット:	Artigo
言語:	Inglês
出版事項:	Wiley 2021-08-01
シリーズ:	Journal of Cachexia, Sarcopenia and Muscle
主題:	Cardiac mitochondria Focused ion beam‐scanning electron microscopy BNIP3 3D morphometry Mitochondrial energetics Mitochondrial dynamics
オンライン･アクセス:	https://doi.org/10.1002/jcsm.12742
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