Administering Bifidobacterium pseudolongum With Arsenic Trioxide Attenuates Acute Promyelocytic Leukemia in Mice by Restoring Immune Microenvironment and Intestinal Homeostasis

Objective: Arsenic trioxide (ATO) is a cornerstone of acute promyelocytic leukemia (APL) therapy but induces severe gut microbiota dysbiosis, limiting its efficacy and safety. This study investigated whether adjunctive Bifidobacterium pseudolongum (BP) could mitigate these adverse...

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Autors principals:	Zhibo Guo, Zengliang Gao, Yanqiu Zhao, Xiaoting Ni, Wenlei Zhang, Longyu Li, Shiao Ren, Qi Li, Dan Guo, Lijuan Yue, Yutong Liu, Liwang Lin, Shengjin Fan, Xin Hai
Format:	Artigo
Idioma:	Inglês
Publicat:	IMR Press 2026-02-01
Col·lecció:	Frontiers in Bioscience-Landmark
Matèries:	arsenic trioxide acute promyelocytic leukemia intestinal homeostasis bone marrow microenvironment bifidobacterium pseudolongum
Accés en línia:	https://www.imrpress.com/journal/FBL/31/2/10.31083/FBL48584
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