Association of circulating proteasome activity with Alzheimer’s pathology and cognitive functions in APOE ε4 carriers

Abstract Background The proteasome is a major intracellular protease complex, but the significance of circulating proteasome activity in Alzheimer’s disease (AD) is not well established. Because APOE ε4 is the strongest genetic risk factor for AD, we examined whether plasma proteasome activity is as...

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Hlavní autoři:	Bon Gook Koo, Ha-Eun Seo, Yejin Yun, Daegyeom Kim, Jae Myeong Kang, Jaelim Cho, Sang-Yoon Lee, Yu Joo Lee, Kee Hyung Park, Min Jae Lee, Young Noh
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2026-02-01
Edice:	Alzheimer’s Research & Therapy
Témata:	Alzheimer’s disease Amyloid APOE ε4 Biomarker Cognition PET
On-line přístup:	https://doi.org/10.1186/s13195-026-01994-w
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