Association of circulating proteasome activity with Alzheimer’s pathology and cognitive functions in APOE ε4 carriers

Abstract Background The proteasome is a major intracellular protease complex, but the significance of circulating proteasome activity in Alzheimer’s disease (AD) is not well established. Because APOE ε4 is the strongest genetic risk factor for AD, we examined whether plasma proteasome activity is as...

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Autores principales:	Bon Gook Koo, Ha-Eun Seo, Yejin Yun, Daegyeom Kim, Jae Myeong Kang, Jaelim Cho, Sang-Yoon Lee, Yu Joo Lee, Kee Hyung Park, Min Jae Lee, Young Noh
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2026-02-01
Colección:	Alzheimer’s Research & Therapy
Materias:	Alzheimer’s disease Amyloid APOE ε4 Biomarker Cognition PET
Acceso en línea:	https://doi.org/10.1186/s13195-026-01994-w
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