Novel Small Molecules Capable of Blocking mtRAS-Signaling Pathway

RAS mutants are involved in approximately 30% of all human cancers and have been regarded as undruggable targets owing to relatively smooth protein surface and obscure binding pockets. In our previous study, we have demonstrated that GNF-7, a multi-targeted kinase inhibitor, possesses potent anti-pr...

Fuld beskrivelse

Bibliografiske detaljer

Principais autores:	Namkyoung Kim, Injae Shin, Younghoon Kim, Eunhye Jeon, Jiwon Lee, Chaeyoung Lee, Yunju Nam, Sumin Lee, Eunhye Ju, Chan Kim, Woolim Son, SeongShick Ryu, Minjoo Ko, Taebo Sim
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2021-12-01
Serier:	Frontiers in Oncology
Fag:	RAS signaling pathway cancers with mtRAS mutated RAS RAS signaling blocker multi-targeted kinase inhibitor GNF-7
Online adgang:	https://www.frontiersin.org/articles/10.3389/fonc.2021.768022/full
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!