Deciphering tumor-intrinsic and immune characteristics in resectable non-small cell lung cancer treated with neoadjuvant pembrolizumab and chemotherapy

Abstract Background Neoadjuvant chemo-immunotherapy (NCIT) aims to improve surgical and survival outcomes of non-small cell lung cancer (NSCLC) patients. However, the clinical application of NCIT still necessitates coordinated immune and molecular biomarker testing. Methods We conducted whole transc...

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Autors principals:	Yulong Chen, Yanjun Su, Ran Zhang, Song Wang, Jiangyan Zhang, Xiaoxuan Sun, Gang Zhao, Qiuxiang Ou, Hua Bao, Jian You
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-10-01
Col·lecció:	Journal of Translational Medicine
Matèries:	Neoadjuvant chemo-immunotherapy Non-small cell lung cancer Pathological response Perioperative Tumor microenvironment
Accés en línia:	https://doi.org/10.1186/s12967-025-06965-7
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