PGC-1α overexpression promotes mitochondrial biogenesis to protect auditory cells against cisplatin-induced cytotoxicity

Abstract. Cisplatin (CDDP)-induced ototoxicity is one of the common adverse effects of cisplatin chemotherapy. Thus far, effective approaches for attenuating hearing loss are unavailable in clinical practice. Mitochondrial biogenesis acts as a master element of mitochondrial health and is necessary...

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Hlavní autoři:	Weijian Zhang, Hao Xiong, Jiaqi Pang, Lan Lai, Zhongwu Su, Hanqing Lin, Bingquan Jian, Haidi Yang, Yiqing Zheng
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Association for the Advancement of Science (AAAS) 2019-06-01
Edice:	Journal of Bio-X Research
On-line přístup:	http://journals.lww.com/10.1097/JBR.0000000000000038
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