Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B

Much of our current understanding of how small-molecule ligands interact with proteins stems from X-ray crystal structures determined at cryogenic (cryo) temperature. For proteins alone, room-temperature (RT) crystallography can reveal previously hidden, biologically relevant alternate conformations...

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Principais autores:	Tamar Skaist Mehlman, Justin T Biel, Syeda Maryam Azeem, Elliot R Nelson, Sakib Hossain, Louise Dunnett, Neil G Paterson, Alice Douangamath, Romain Talon, Danny Axford, Helen Orins, Frank von Delft, Daniel A Keedy
格式:	Artigo
語言:	Inglês
出版:	eLife Sciences Publications Ltd 2023-03-01
叢編:	eLife
主題:	ligands X-ray crystallography protein structure allostery fragment screening
在線閱讀:	https://elifesciences.org/articles/84632
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