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Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B

Much of our current understanding of how small-molecule ligands interact with proteins stems from X-ray crystal structures determined at cryogenic (cryo) temperature. For proteins alone, room-temperature (RT) crystallography can reveal previously hidden, biologically relevant alternate conformations...

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Principais autores: Tamar Skaist Mehlman, Justin T Biel, Syeda Maryam Azeem, Elliot R Nelson, Sakib Hossain, Louise Dunnett, Neil G Paterson, Alice Douangamath, Romain Talon, Danny Axford, Helen Orins, Frank von Delft, Daniel A Keedy
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2023-03-01
coleção:eLife
Assuntos:
ligands
X-ray crystallography
protein structure
allostery
fragment screening
Acesso em linha:https://elifesciences.org/articles/84632
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