An allelic atlas of immunoglobulin heavy chain variable regions reveals antibody binding epitope preference resilient to SARS-CoV-2 mutation escape

BackgroundAlthough immunoglobulin (Ig) alleles play a pivotal role in the antibody response to pathogens, research to understand their role in the humoral immune response is still limited.MethodsWe retrieved the germline sequences for the IGHV from the IMGT database to illustrate the amino acid poly...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Weiqi Deng, Xuefeng Niu, Ping He, Qihong Yan, Huan Liang, Yongping Wang, Lishan Ning, Zihan Lin, Yudi Zhang, Xinwei Zhao, Liqiang Feng, Linbing Qu, Ling Chen
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2025-01-01
Цуврал:	Frontiers in Immunology
Нөхцлүүд:	allele affinity antibody epitopes immunoglobulin heavy chain (Igh) neutralization
Онлайн хандалт:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1471396/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!