Identification of Novel Cathepsin B Inhibitors with Implications in Alzheimer’s Disease: Computational Refining and Biochemical Evaluation

Amyloid precursor protein (APP), upon proteolytic degradation, forms aggregates of amyloid β (Aβ) and plaques in the brain, which are pathological hallmarks of Alzheimer’s disease (AD). Cathepsin B is a cysteine protease enzyme that catalyzes the proteolytic degradation of APP in the brain. Thus, ca...

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Główni autorzy:	Nitin Chitranshi, Ashutosh Kumar, Samran Sheriff, Veer Gupta, Angela Godinez, Danit Saks, Soumalya Sarkar, Ting Shen, Mehdi Mirzaei, Devaraj Basavarajappa, Morteza Abyadeh, Sachin K. Singh, Kamal Dua, Kam Y. J. Zhang, Stuart L. Graham, Vivek Gupta
Format:	Artigo
Język:	Inglês
Wydane:	MDPI AG 2021-07-01
Seria:	Cells
Hasła przedmiotowe:	Alzheimer’s disease cathepsin B 3D pharmacophore virtual screening docking molecular dynamics
Dostęp online:	https://www.mdpi.com/2073-4409/10/8/1946
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