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Identification of Novel Cathepsin B Inhibitors with Implications in Alzheimer’s Disease: Computational Refining and Biochemical Evaluation

Amyloid precursor protein (APP), upon proteolytic degradation, forms aggregates of amyloid β (Aβ) and plaques in the brain, which are pathological hallmarks of Alzheimer’s disease (AD). Cathepsin B is a cysteine protease enzyme that catalyzes the proteolytic degradation of APP in the brain. Thus, ca...

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Автори: Nitin Chitranshi, Ashutosh Kumar, Samran Sheriff, Veer Gupta, Angela Godinez, Danit Saks, Soumalya Sarkar, Ting Shen, Mehdi Mirzaei, Devaraj Basavarajappa, Morteza Abyadeh, Sachin K. Singh, Kamal Dua, Kam Y. J. Zhang, Stuart L. Graham, Vivek Gupta
Формат: Artigo
Мова:Inglês
Опубліковано: MDPI AG 2021-07-01
Серія:Cells
Предмети:
Alzheimer’s disease
cathepsin B
3D pharmacophore
virtual screening
docking
molecular dynamics
Онлайн доступ:https://www.mdpi.com/2073-4409/10/8/1946
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