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l-[5-11C]Glutamine PET imaging noninvasively tracks dynamic responses of glutaminolysis in non-alcoholic steatohepatitis

Inhibiting glutamine metabolism has been proposed as a potential treatment strategy for improving non-alcoholic steatohepatitis (NASH). However, effective methods for assessing dynamic metabolic responses during interventions targeting glutaminolysis have not yet emerged. Here, we developed a positr...

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Principais autores: Yiding Zhang, Lin Xie, Masayuki Fujinaga, Yusuke Kurihara, Masanao Ogawa, Katsushi Kumata, Wakana Mori, Tomomi Kokufuta, Nobuki Nengaki, Hidekatsu Wakizaka, Rui Luo, Feng Wang, Kuan Hu, Ming-Rong Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-02-01
Serier:Acta Pharmaceutica Sinica B
Fag:
l-[5-11C]Glutamine
Positron emission tomography
Non-alcoholic steatohepatitis
Glutaminolysis
Glutaminase 1
Metabolic intervention
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211383524003137
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