Intestinal epithelial-derived TAK1 signaling is essential for cytoprotection against chemical-induced colitis.

<h4>Background</h4>We have previously reported that intestinal epithelium-specific TAK1 deleted mice exhibit severe inflammation and mortality at postnatal day 1 due to TNF-induced epithelial cell death. Although deletion of TNF receptor 1 (TNFR1) can largely rescue those neonatal phenotypes, mice h...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Jae-Young Kim, Rie Kajino-Sakamoto, Emily Omori, Christian Jobin, Jun Ninomiya-Tsuji
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Public Library of Science (PLoS) 2009-01-01
Schriftenreihe:	PLoS ONE
Online-Zugang:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0004561&type=printable
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!