TALENs Facilitate Single-step Seamless SDF Correction of F508del CFTR in Airway Epithelial Submucosal Gland Cell-derived CF-iPSCs

Cystic fibrosis (CF) is a recessive inherited disease associated with multiorgan damage that compromises epithelial and inflammatory cell function. Induced pluripotent stem cells (iPSCs) have significantly advanced the potential of developing a personalized cell-based therapy for diseases like CF by...

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Principais autores:	Shingo Suzuki, R Geoffrey Sargent, Beate Illek, Horst Fischer, Alaleh Esmaeili-Shandiz, Michael J Yezzi, Albert Lee, Yanu Yang, Soya Kim, Peter Renz, Zhongxia Qi, Jingwei Yu, Marcus O Muench, Ashley I Beyer, Alessander O Guimarães, Lin Ye, Judy Chang, Eli J Fine, Thomas J Cradick, Gang Bao, Meghdad Rahdar, Matthew H Porteus, Tsuyoshi Shuto, Hirofumi Kai, Yuet W Kan, Dieter C Gruenert
格式:	Artigo
語言:	Inglês
出版:	Elsevier 2016-01-01
叢編:	Molecular Therapy: Nucleic Acids
主題:	cystic fibrosis iPS cells iPSC directed differentiation polynucleotide gene targeting/genome editing sequence-specific chimeric endonucleases SFHR
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S2162253116300099
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