Automated design of CRISPR prime editors for 56,000 human pathogenic variants

Summary: Prime editors (PEs) are clustered regularly interspaced short palindromic repeats (CRISPR)-based genome engineering tools that can introduce precise base-pair edits. We developed an automated pipeline to correct (therapeutic editing) or introduce (disease modeling) human pathogenic variants...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	John A. Morris, Jahan A. Rahman, Xinyi Guo, Neville E. Sanjana
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2021-11-01
Schriftenreihe:	iScience
Schlagworte:	Biotechnology Computational bioinformatics
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2589004221013511
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