Automated design of CRISPR prime editors for 56,000 human pathogenic variants
Summary: Prime editors (PEs) are clustered regularly interspaced short palindromic repeats (CRISPR)-based genome engineering tools that can introduce precise base-pair edits. We developed an automated pipeline to correct (therapeutic editing) or introduce (disease modeling) human pathogenic variants...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier
2021-11-01
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| Col·lecció: | iScience |
| Matèries: | |
| Accés en línia: | http://www.sciencedirect.com/science/article/pii/S2589004221013511 |
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