Federated analysis of BRCA1 and BRCA2 variation in a Japanese cohort

Summary: More than 40% of the germline variants in ClinVar today are variants of uncertain significance (VUSs). These variants remain unclassified in part because the patient-level data needed for their interpretation is siloed. Federated analysis can overcome this problem by “bringing the code to t...

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Autores principales:	James Casaletto, Michael Parsons, Charles Markello, Yusuke Iwasaki, Yukihide Momozawa, Amanda B. Spurdle, Melissa Cline
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2022-03-01
Colección:	Cell Genomics
Materias:	Variant of uncertain significance federated computing variant classification benign pathogenic data privacy
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2666979X22000295
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