Breast cancer surgery in the era of genetic uncertainty: real-world outcomes in BRCA1/2 pathogenic variants and variants of uncertain significance

Abstract Background Germline testing for BRCA1 and BRCA2 has become integral to the management of breast cancer, with pathogenic variants strongly influencing surgical decision-making. However, the increasing detection of variants of uncertain significance (VUS) presents a major clinical challenge,...

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Autori principali:	Ilker Nihat Ökten, Tuba Baydaş, Sinan Koca, Mukaddes Feyza Baltacı, Filiz Özen, İbrahim Çil, Metin Eser, Adnan Gündoğdu, Merve Aktaş, Osman Cem Yılmaz
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2026-02-01
Serie:	BMC Cancer
Soggetti:	Breast cancer BRCA1 and BRCA2 Variants of uncertain significance Bilateral mastectomy Surgical decision-making
Accesso online:	https://doi.org/10.1186/s12885-026-15721-z
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