Detection of glucose-derived d- and l-lactate in cancer cells by the use of a chiral NMR shift reagent

Abstract Background Excessive lactate production, a hallmark of cancer, is largely formed by the reduction of pyruvate via lactate dehydrogenase (LDH) to l-lactate. Although d-lactate can also be produced from glucose via the methylglyoxal pathway in small amounts, less is known about the amount of...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Eul Hyun Suh, Carlos F. G. C. Geraldes, Sara Chirayil, Brandon Faubert, Raul Ayala, Ralph J. DeBerardinis, A. Dean Sherry
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2021-11-01
Цуврал:	Cancer & Metabolism
Нөхцлүүд:	d- and l-lactate Shift reagent-aided NMR Cancer cells
Онлайн хандалт:	https://doi.org/10.1186/s40170-021-00267-4
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!