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Detection of glucose-derived d- and l-lactate in cancer cells by the use of a chiral NMR shift reagent

Abstract Background Excessive lactate production, a hallmark of cancer, is largely formed by the reduction of pyruvate via lactate dehydrogenase (LDH) to l-lactate. Although d-lactate can also be produced from glucose via the methylglyoxal pathway in small amounts, less is known about the amount of...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Eul Hyun Suh, Carlos F. G. C. Geraldes, Sara Chirayil, Brandon Faubert, Raul Ayala, Ralph J. DeBerardinis, A. Dean Sherry
Hōputu: Artigo
Reo:Inglês
I whakaputaina: BMC 2021-11-01
Rangatū:Cancer & Metabolism
Ngā marau:
Urunga tuihono:https://doi.org/10.1186/s40170-021-00267-4
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