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Comprehensive Data-Driven Assessment of Non-Kinase Targets of Inhibitors of the Human Kinome

Protein kinases (PKs) are involved in many intracellular signal transduction pathways through phosphorylation cascades and have become intensely investigated pharmaceutical targets over the past two decades. Inhibition of PKs using small-molecular inhibitors is a premier strategy for the treatment o...

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Principais autores: Mona Mobasher, Martin Vogt, Elena Xerxa, Jürgen Bajorath
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-02-01
Serier:Biomolecules
Fag:
protein kinases
human kinome
kinase inhibitors
activity data
multi-target activity
non-kinase targets
Online adgang:https://www.mdpi.com/2218-273X/14/3/258
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