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Decapping factor Dcp2 controls mRNA abundance and translation to adjust metabolism and filamentation to nutrient availability

Degradation of most yeast mRNAs involves decapping by Dcp1/Dcp2. DEAD-box protein Dhh1 has been implicated as an activator of decapping, in coupling codon non-optimality to enhanced degradation, and as a translational repressor, but its functions in cells are incompletely understood. RNA-Seq analyse...

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Principais autores: Anil Kumar Vijjamarri, Xiao Niu, Matthew D Vandermeulen, Chisom Onu, Fan Zhang, Hongfang Qiu, Neha Gupta, Swati Gaikwad, Miriam L Greenberg, Paul J Cullen, Zhenguo Lin, Alan G Hinnebusch
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2023-06-01
coleção:eLife
Assuntos:
decapping
degradation
translation
Dcp2
Dhh1
NMD
Acesso em linha:https://elifesciences.org/articles/85545
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