Musashi-2 Deficiency Triggers Colorectal Cancer Ferroptosis by Downregulating the MAPK Signaling Cascade to Inhibit HSPB1 Phosphorylation

Abstract Background Musashi-2 (MSI2) is a critical RNA-binding protein (RBP) whose ectopic expression drives the pathogenesis of various cancers. Accumulating evidence suggests that inducing ferroptosis of tumor cells can inhibit their malignant biological behavior as a promising therapeutic approac...

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Hlavní autoři:	Xiaole Meng, Xiao Peng, Wanxin Ouyang, Hui Li, Risi Na, Wenting Zhou, Xuting You, Yuhuan Li, Xin Pu, Ke Zhang, Junjie Xia, Jie Wang, Guohong Zhuang, Huamei Tang, Zhihai Peng
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2023-12-01
Edice:	Biological Procedures Online
Témata:	Musashi-2 (MSI2) HSPB1 Ferroptosis Colorectal Cancer (CRC)
On-line přístup:	https://doi.org/10.1186/s12575-023-00222-1
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