Musashi-2 Deficiency Triggers Colorectal Cancer Ferroptosis by Downregulating the MAPK Signaling Cascade to Inhibit HSPB1 Phosphorylation

Abstract Background Musashi-2 (MSI2) is a critical RNA-binding protein (RBP) whose ectopic expression drives the pathogenesis of various cancers. Accumulating evidence suggests that inducing ferroptosis of tumor cells can inhibit their malignant biological behavior as a promising therapeutic approac...

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Detalhes bibliográficos

Principais autores:	Xiaole Meng, Xiao Peng, Wanxin Ouyang, Hui Li, Risi Na, Wenting Zhou, Xuting You, Yuhuan Li, Xin Pu, Ke Zhang, Junjie Xia, Jie Wang, Guohong Zhuang, Huamei Tang, Zhihai Peng
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-12-01
coleção:	Biological Procedures Online
Assuntos:	Musashi-2 (MSI2) HSPB1 Ferroptosis Colorectal Cancer (CRC)
Acesso em linha:	https://doi.org/10.1186/s12575-023-00222-1
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