Increased slow dynamics defines ligandability of BTB domains
Here, the authors discover that ligandability of BTB domains correlates with the presence of μs-ms time scale dynamics. This finding suggests that protein dynamics may be a broadly applicable tool in drug discovery to assess the ligandability of novel and challenging targets.
Tallennettuna:
| Päätekijät: | , , , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Nature Portfolio
2022-11-01
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| Sarja: | Nature Communications |
| Linkit: | https://doi.org/10.1038/s41467-022-34599-6 |
| Tagit: |
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