A Unique Trimeric Assembly of Human Dishevelled 1 PDZ Domain in Crystal: Implication of Homo- and Hetero-Oligomerization During Wnt Signaling Process

Wnt/β-catenin signaling is hyper-activated in several cancer cells and cancer stem cells. Dishevelled/Dvl is a key adapter protein that acts as a bridge between the Wnt receptor Frizzled (Fzd) and other cytosolic factors. In detail, the C-terminal cytosolic region is the ligand of the PSD-95, disks...

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Principais autores:	Shotaro Yasukochi, Nobutaka Numoto, Kiminori Hori, Takeshi Tenno, Emi Hibino, Nobutoshi Ito, Hidekazu Hiroaki
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2025-08-01
coleção:	Molecules
Assuntos:	PDZ domain trimeric assembly auto-inhibiting trimer ligand-binding cleft liquid–liquid phase separation Dvl-Axin hetero-oligomerization
Acesso em linha:	https://www.mdpi.com/1420-3049/30/17/3538
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