Genetically engineered macrophages delivering TRAIL targeting the Wnt/β-catenin pathway to induce cytotoxicity against TNBC

Abstract Triple-negative breast cancer (TNBC) is a highly aggressive cancer subtype that lacks effective targeted therapies, posing significant challenges in its treatment. Engineered macrophages have emerged as promising tools for drug delivery and immunotherapy in cancer treatment. In this study,...

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Principais autores:	Mingyao Huang, Xin Yu, Zirong Jiang, Xiaofen Li, Shuo Yang, Shiping Luo, Chuangui Song
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-01-01
Colecção:	Cell Communication and Signaling
Assuntos:	TRAIL Engineered macrophages Pro-inflammatory TNBC Wnt/β-catenin
Acesso em linha:	https://doi.org/10.1186/s12964-025-02394-7
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