Glutaredoxin 1 promotes intestinal epithelial cell copper toxicity in inflammatory bowel disease

Protein S-glutathionylation (PSSG), a redox-sensitive post-translational modification, regulates protein conformation and activity, potentially resulting in cell death. PSSG is dynamically reversed by glutaredoxin 1 (GRX1), a critical oxidoreductase. Here, we observed elevated PSSG levels in colonic...

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Autori principali:	Tiantian Zhang, Xiaofen Zhang, Huimei Cai, Mengli Yu, Qichen Liu, Xin Song, Bingru Lin, Linjie Xu, Lan Li, Zhe Shen, Chaohui Yu, Jie Zhang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2026-06-01
Serie:	Redox Biology
Soggetti:	Ulcerative colitis Protein S-Glutathionylation Glutaredoxin 1 Copper toxicity ATPase copper-transporting beta
Accesso online:	http://www.sciencedirect.com/science/article/pii/S221323172600162X
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