A metformin add-on clinical study in multiple sclerosis to evaluate brain remyelination and neurodegeneration (MACSiMiSE-BRAIN): study protocol for a multi-center randomized placebo controlled clinical trial

IntroductionDespite advances in immunomodulatory treatments of multiple sclerosis (MS), patients with non-active progressive multiple sclerosis (PMS) continue to face a significant unmet need. Demyelination, smoldering inflammation and neurodegeneration are important drivers of disability progressio...

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Главные авторы:	Anna-Victoria De Keersmaecker, Eline Van Doninck, Veronica Popescu, Lander Willem, Melissa Cambron, Guy Laureys, Miguel D’ Haeseleer, Maria Bjerke, Ella Roelant, Marc Lemmerling, Marie Beatrice D’hooghe, Judith Derdelinckx, Tatjana Reynders, Barbara Willekens
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2024-02-01
Серии:	Frontiers in Immunology
Предметы:	progressive multiple sclerosis metformin remyelination neurodegeneration neuroprotection clinical trial
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1362629/full
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