A metformin add-on clinical study in multiple sclerosis to evaluate brain remyelination and neurodegeneration (MACSiMiSE-BRAIN): study protocol for a multi-center randomized placebo controlled clinical trial

IntroductionDespite advances in immunomodulatory treatments of multiple sclerosis (MS), patients with non-active progressive multiple sclerosis (PMS) continue to face a significant unmet need. Demyelination, smoldering inflammation and neurodegeneration are important drivers of disability progressio...

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Ngā kaituhi matua:	Anna-Victoria De Keersmaecker, Eline Van Doninck, Veronica Popescu, Lander Willem, Melissa Cambron, Guy Laureys, Miguel D’ Haeseleer, Maria Bjerke, Ella Roelant, Marc Lemmerling, Marie Beatrice D’hooghe, Judith Derdelinckx, Tatjana Reynders, Barbara Willekens
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Frontiers Media S.A. 2024-02-01
Rangatū:	Frontiers in Immunology
Ngā marau:	progressive multiple sclerosis metformin remyelination neurodegeneration neuroprotection clinical trial
Urunga tuihono:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1362629/full
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!