Undetectable off-target effects induced by FokI catalytic domain in mouse embryos

Abstract The FokI catalytic domain can be fused to various DNA binding architectures to improve the precision of genome editing tools. However, evaluation of off-target effects is essential for developing these tools. We use Genome-wide Off-target analysis by Two-cell embryo Injection (GOTI) to dete...

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Үндсэн зохиолчид:	Long Xie, Hu Feng, Zhifang Li, Di Li, Xiali Yang, Tanglong Yuan, Nana Yan, Chenfei He, Jitan Zheng, Zhenrui Zuo, Yaxuan Zheng, Yaqi Cao, Yangqing Lu, Xing Yao Xiong, Erwei Zuo
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2024-02-01
Цуврал:	Genome Biology
Онлайн хандалт:	https://doi.org/10.1186/s13059-024-03188-9
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!