Undetectable off-target effects induced by FokI catalytic domain in mouse embryos

Abstract The FokI catalytic domain can be fused to various DNA binding architectures to improve the precision of genome editing tools. However, evaluation of off-target effects is essential for developing these tools. We use Genome-wide Off-target analysis by Two-cell embryo Injection (GOTI) to dete...

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Autors principals:	Long Xie, Hu Feng, Zhifang Li, Di Li, Xiali Yang, Tanglong Yuan, Nana Yan, Chenfei He, Jitan Zheng, Zhenrui Zuo, Yaxuan Zheng, Yaqi Cao, Yangqing Lu, Xing Yao Xiong, Erwei Zuo
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2024-02-01
Col·lecció:	Genome Biology
Accés en línia:	https://doi.org/10.1186/s13059-024-03188-9
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