Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR

Abstract Background In the event of amino acid starvation, the cell activates two main protective pathways: Amino Acid starvation Response (AAR), to inhibit global translation, and autophagy, to recover the essential substrates from degradation of redundant self-components. Whether and how AAR and a...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Carlo Follo, Chiara Vidoni, Federica Morani, Alessandra Ferraresi, Christian Seca, Ciro Isidoro
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2019-05-01
Schriftenreihe:	Cell Communication and Signaling
Schlagworte:	Autophagy Starvation mTORC1 Lysosome TFEB Protein translation
Online-Zugang:	http://link.springer.com/article/10.1186/s12964-019-0354-2
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!