Neuroimaging Biomarkers of mTOR Inhibition on Vascular and Metabolic Functions in Aging Brain and Alzheimer’s Disease

The mechanistic target of rapamycin (mTOR) is a nutrient sensor of eukaryotic cells. Inhibition of mechanistic mTOR signaling can increase life and health span in various species via interventions that include rapamycin and caloric restriction (CR). In the central nervous system, mTOR inhibition dem...

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主要な著者:	Jennifer Lee, Lucille M. Yanckello, David Ma, Jared D. Hoffman, Ishita Parikh, Scott Thalman, Bjoern Bauer, Anika M. S. Hartz, Fahmeed Hyder, Ai-Ling Lin
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2018-07-01
シリーズ:	Frontiers in Aging Neuroscience
主題:	mechanistic target of rapamycin (mTOR) rapamycin caloric restriction ketogentic diet MRI PET
オンライン･アクセス:	https://www.frontiersin.org/article/10.3389/fnagi.2018.00225/full
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