Protein C in adult patients with sepsis: from pathophysiology to monitoring and supplementation

Abstract Protein C (PC) plays a crucial role in modulating inflammation and coagulation in sepsis. Its anticoagulant and cytoprotective properties are critical in mitigating sepsis-induced coagulopathy, which is associated with high mortality rates. In sepsis, low levels of PC are associated with an...

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Autori principali:	Irene Coloretti, Antonio Corcione, Gennaro De Pascale, Abele Donati, Francesco Forfori, Marco Marietta, Mauro Panigada, Paolo Simioni, Carlo Tascini, Pierluigi Viale, Massimo Girardis
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-04-01
Serie:	Journal of Anesthesia, Analgesia and Critical Care
Soggetti:	Sepsis Septic shock Thrombosis Disseminated intravascular coagulation Activated protein C
Accesso online:	https://doi.org/10.1186/s44158-025-00243-0
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