Loss-of-function mitochondrial DNA polymerase gamma variants cause vascular smooth muscle cells to secrete a diffusible mitogenic factor

IntroductionMitochondrial dysfunction promotes vascular aging and disease through diverse mechanisms beyond metabolic supply, including calcium and radical signaling and inflammation. Mitochondrial DNA (mtDNA) replication by the POLG-encoded mitochondrial DNA polymerase (POLG) is critical for mitoch...

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主要な著者:	Samantha Rothwell, Irvin Ng, Sophia Shalchy-Tabrizi, Pola Kalinowski, Omnia M. Taha, Italia Paris, Angelica Baniqued, Lisa Lin, Michelle M. Mezei, Anna Lehman, Lisa M. Julian, Damon Poburko
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2025-02-01
シリーズ:	Frontiers in Physiology
主題:	IncuCyte StarDist A7r5 mitochondrial DNA hypertension rare disease
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fphys.2024.1488248/full
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