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Loss-of-function mitochondrial DNA polymerase gamma variants cause vascular smooth muscle cells to secrete a diffusible mitogenic factor

IntroductionMitochondrial dysfunction promotes vascular aging and disease through diverse mechanisms beyond metabolic supply, including calcium and radical signaling and inflammation. Mitochondrial DNA (mtDNA) replication by the POLG-encoded mitochondrial DNA polymerase (POLG) is critical for mitoch...

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Bibliografiske detaljer
Principais autores: Samantha Rothwell, Irvin Ng, Sophia Shalchy-Tabrizi, Pola Kalinowski, Omnia M. Taha, Italia Paris, Angelica Baniqued, Lisa Lin, Michelle M. Mezei, Anna Lehman, Lisa M. Julian, Damon Poburko
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-02-01
Serier:Frontiers in Physiology
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Online adgang:https://www.frontiersin.org/articles/10.3389/fphys.2024.1488248/full
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