Design, Synthesis, Molecular Modeling, and Anticancer Evaluation of New VEGFR-2 Inhibitors Based on the Indolin-2-One Scaffold

A new series of indoline-2-one derivatives was designed and synthesized based on the essential pharmacophoric features of VEGFR-2 inhibitors. Anti-proliferative activities were assessed for all derivatives against breast (MCF-7) and liver (HepG2) cancer cell lines, using sunitinib as a reference age...

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Hlavní autoři:	Mohamed A. Abdelgawad, Alaa M. Hayallah, Syed Nasir Abbas Bukhari, Arafa Musa, Mohammed Elmowafy, Hamdy M. Abdel-Rahman, Mohammed K. Abd El-Gaber
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2022-11-01
Edice:	Pharmaceuticals
Témata:	anti-proliferative apoptosis indolin-2-one isatin docking sunitinib
On-line přístup:	https://www.mdpi.com/1424-8247/15/11/1416
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