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Parkin activates innate immunity and promotes antitumor immune responses

The activation of innate immunity and associated interferon (IFN) signaling have been implicated in cancer, but the regulators are elusive and links to tumor suppression remain undetermined. Here, we found that Parkin, an E3 ubiquitin ligase altered in Parkinson’s Disease, was epigenetically silence...

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Furkejuvvon:
Váldodahkkit: Michela Perego, Minjeong Yeon, Ekta Agarwal, Andrew T. Milcarek, Irene Bertolini, Chiara Camisaschi, Jagadish C. Ghosh, Hsin-Yao Tang, Nathalie Grandvaux, Marcus Ruscetti, Andrew V. Kossenkov, Sarah Preston-Alp, Italo Tempera, Noam Auslander, Dario C. Altieri
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: American Society for Clinical Investigation 2025-01-01
Ráidu:The Journal of Clinical Investigation
Fáttát:
Immunology
Oncology
Liŋkkat:https://doi.org/10.1172/JCI180983
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