Mertk+ Liver Sinusoidal Endothelial Cells Negatively Regulate PINK1 Related Mitophagy and Accelerate MASH

ABSTRACT Background Mer tyrosine kinase (Mertk) regulating mitochondrial function of liver sinusoidal endothelial cells (LSECs) in metabolic dysfunction‐associated steatohepatitis (MASH) remains unclear. Methods Mertk/p‐Mertk, PINK1, and ERK/p‐ERK expression in steatotic LSECs and livers of MASH mic...

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Autori principali:	Yu‐Xuan Gao, Zhong Weng, Long Tang, Ming‐Yi Xu, Sheng‐Zheng Luo
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2025-09-01
Serie:	Immunity, Inflammation and Disease
Soggetti:	extracellular regulated protein kinase (ERK) liver sinusoidal endothelial cell (LSEC) Mer tyrosine kinase (Mertk) metabolic dysfunction‐associated steatohepatitis (MASH) mitophagy PTEN‐induced putative kinase 1 (PINK1)
Accesso online:	https://doi.org/10.1002/iid3.70256
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